22 July 2026
A platform for synthesizing highly desirable C-glycoside molecules from sugar has been developed that uses glycosyl sulfonyl hydrazides as readily accessible free-radical precursors. The strategy enables targeted formation of carbon–carbon bonds across carbohydrate scaffolds and with specificity for the desired 3D arrangement of atoms.
This is a summary of: Guo, Y. et al. C-glycoside synthesis through radical cross-coupling of glycohydrazides. Nature https://doi.org/10.1038/s41586-026-10807-x (2026).
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