Some cancer cells can enter a dormant, sleep-like state that helps them survive treatment. Instead of continuing to grow and divide, these cells become largely inactive, allowing them to avoid the effects of many cancer drugs.
In certain forms of cancer, including some types of lung cancer, stress hormones can trigger this response. Specialized proteins called glucocorticoid receptors detect those hormones inside tumor cells. Once activated, the receptors can push the cells into a dormant state where cell division slows dramatically. As a result, many therapies become far less effective.
Researchers have been searching for ways to disable these receptors and wake the cancer cells from dormancy, making them easier to target and destroy.
Using Light To Target Tumor Cells
A major challenge is that glucocorticoid receptors are found throughout the body, not just in cancer cells. These receptors play essential roles in controlling inflammation and supporting normal immune system function.
