03 June 2026
An innovative method of mass spectrometry has detected the small protein ubiquitin on biomolecules other than proteins. In mouse liver, the energy-storing molecule glycogen has a large increase in ubiquitination — involving 1% of the liver’s total ubiquitin — during fasting, when glycogen is broken down.
This is a summary of: Jochem, M. et al. Ubiquitination of glycogen and metabolites in cells and tissues. Nature https://doi.org/10.1038/s41586-026-10548-x (2026).
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