Patients in full remission from endometrial cancer who underwent fertility-preserving treatment before cancer treatment had less IVF success than matched controls.The question remains as to what exactly drives this difference in pregnancy outcomes.Authors noted that findings show preserving the uterus doesn't necessarily preserve endometrial function, which should be considered in patient counseling.
Functional endometrial recovery was not a sure thing for patients who underwent fertility-sparing treatment before endometrial cancer treatment, researchers from China reported.
In the retrospective cohort study, patients who underwent fertility-sparing treatment before endometrial cancer treatment and then did in-vitro fertilization (IVF) after histologic complete remission had less success than their counterparts without cancer, according to Peng Peng, MD, of the National Clinical Research Center for Women's Health and Obstetric and Gynecologic Diseases in Beijing, and colleagues.
In the first frozen-thawed embryo transfer cycle, those with a history of endometrial cancer or endometrial intraepithelial neoplasia (EIN; severe precancerous lesions) had significantly lower rates of clinical pregnancy than the matched control group (37.3% vs 61.1%, P<0.001), they stated in Obstetrics & Gynecology.
