Justice Minister Carlo Nordio's Chief of Staff Giusi Bartolozzi and Justice Undersecretary Andrea Delmastro Delle Vedove on Tuesday resigned after becoming embroiled in separate furores seen as damaging the government campaign to win a referendum on Nordio's Constitutional reform of the justice system, which the Giorgia Meloni-led government went on to lose.

Bartolozzi was heavily criticised in the campaign for the referendum after saying that the judiciary were a firing squad that had to be eliminated, a remark seen as revealing the true goal of the reform and for which she had to embarrassingly apologise.

Delmastro has come under fire for becoming the partner in a Rome restaurant with the 18-year-old daughter of the convicted front man for the capital's top Neapolitan Camorra mafia boss Michele Senese.

Delmastro issued a statement saying he had done nothing wrong.

"Today I signed my irrevocable resignation as Undersecretary of Justice," he said.