A toddler in Italy who received a damaged donor heart has died, the family's lawyer has said.
Two-year-old Domenico died shortly before 09:30 local time (08:30 GMT) on Saturday, Francesco Petruzzi told reporters. Monaldi Hospital, where he was being treated, said he had suffered a "sudden and irreversible worsening of his clinical condition".
The heart given to Domenico during a transplant in late December was reportedly transported to the hospital in direct contact with dry ice, causing severe tissue damage.
Prosecutors have opened an investigation into the incident and six medics have been placed under formal investigation in a case which has sparked outrage in Italy.
Petruzzi has said the organ arrived "burned by frostbite" after being transported over 800km (490 miles) from Bolzano to Naples in an unsuitable container alongside the ice, without a thermometer to alert the medical team to the low temperature.
