A key role for retrograde neuromodulatory signalling in motivated behaviour is shown through dynamic endocannabinoid release within a thalamostriatal circuit that regulates behavioural engagement during reward seeking.
Data availability
All data associated with this project have been uploaded to Figshare (https://figshare.com/authors/David_Marcus/23255861).
Code availability
All code associated with this project has been uploaded to Figshare (https://figshare.com/authors/David_Marcus/23255861).
ReferencesDevane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S. & Howlett, A. C. Determination and characterization of a cannabinoid receptor in rat brain. Mol. Pharmacol. 34, 605–613 (1988).Article
Hippocampal–neocortical communication reconfigures predetermined circuit motifs to flexibly encode experiences.
Cell-type-specific opioid blockade in accumbal cholinergic interneurons abolishes morphine-reward learning without impairing…
Scientists have uncovered a key brain signal that helps us break old habits and adapt when circumstances suddenly change. By…
Brain-wide transcriptomic profiling in mice reveals that reproductive experience remodels the maternal brain by altering dopamine…
Stimulation of human cortex reorganizes neural assemblies and induces cell-type-specific gene regulatory programs, establishing…
A group of brain cells called orexin neurons appears to help us keep working when reaching a reward becomes increasingly…
