22 July 2026
Rerunning tumour evolution in mice shows how cancer develops after DNA damage and reveals that background genetics and acquired mutations interact to shape genome stability and selection. This provides experimental evidence that genetic ancestry has an important role in setting the trajectory of cancer evolution.
This is a summary of: Aitken, S. J. et al. Genetic background sets the trajectory of experimental cancer evolution. Nature https://doi.org/10.1038/s41586-026-10821-z (2026).
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