Data availability
The RNA-seq data generated in this study are available at the Gene Expression Omnibus under accession number GSE274219. The WGS data generated in this study are available at the Sequence Read Archive under the accession number PRJNA1146341 and gene-level copy-number calls are provided at Figshare99 (https://doi.org/10.6084/m9.figshare.32144932). METABRIC and TCGA data used in this study are publicly available (https://www.cbioportal.org/datasets and https://xenabrowser.net/datapages/). The list of OncoKB Cancer Genes is available online (https://oncokb.org/cancer-genes). Human scRNA-seq data are available at the Gene Expression Omnibus under accession number GSE176078 (ref. 16) and GSE161529 (ref. 17) and at https://lambrechtslab.sites.vib.be/en/dataaccess (refs. 18,19). Source data are provided with this paper.
Code availabilityNo new code was developed to analyse data within this study. Single-cell data processing and human CNA analysis scripts are available at GitHub (https://www.github.com/dpcook/blbc_cna). Links and references to established code for all other analyses, along with any minor modifications are provided within the relevant Methods sections.ReferencesHolland, A. J. & Cleveland, D. W. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat. Rev. Mol. Cell Biol. 10, 478–487 (2009).Article
