08 July 2026
Cancer genomes are unstable, often experiencing gains or losses of whole chromosomes or chromosome arms — changes known as aneuploidies. Experiments in mouse models of breast cancer reveal that these instabilities harbour one or two prevalent genes that drive cancer and that bypass the need to accumulate aneuploidies; they also require an intact microenvironment to produce their effects.
This is a summary of: Al-Zahrani, K. N. et al. Aneuploidy selects for the acquisition of driver genes in breast cancer. Nature https://doi.org/10.1038/s41586-026-10752-9 (2026).
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