Long-term immune function impairment reduces the immune system's ability to clear persistent HPV infection and keep precancerous lesions from becoming cancerous.In a retrospective study from Sweden, the likelihood of developing any HPV-related cancer was over four times higher for people with HIV compared with matched population controls.Odds of these cancers in organ transplant recipients was more than two times higher, and observed after heart, lung, liver, and kidney transplantation.
People with HIV and solid organ transplant recipients were significantly more likely to develop human papillomavirus (HPV)-associated anal, penile, vulvar, and cervical cancers, according to a Swedish retrospective case-control study.
Compared with age- and sex-matched controls in the general population, people with HIV were over four times more likely to develop any HPV-related cancer (adjusted odds ratio [aOR] 4.50, 95% CI 3.46-5.84), reported Christina Carlander, MD, PhD, of the Karolinska Institutet in Stockholm, and colleagues.
And transplant recipients had more than double the likelihood (aOR 2.23, 95% CI 1.85-2.68), with significantly increased odds observed after heart (aOR 2.91), lung (aOR 2.71), kidney (aOR 2.17), and liver (aOR 1.89) transplant, the findings in JAMA Network Open showed.
