Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover - Nature

Data availabilityAll data supporting the findings of this study are available within the article and its Supplementary Information, the latter of which includes uncropped Western blot scans, genotyping primer sequences, qPCR primer sequences, shRNA oligo sequences and sgRNA oligo sequences. Publicly available rare-variant burden association results in humans (Table 1) were obtained from the GeneBass database (https://app.genebass.org). Mass spectrometry data from mouse liver tissues overexpressing RalA-WT, RalA(G23V) or RalA(S28N) have been deposited in FigShare under https://doi.org/10.6084/m9.figshare.32229999 (ref. 57). Source data are provided with this paper.Code availabilityNo custom code was used in this study.ReferencesGoldstein, J. L. & Brown, M. S. A century of cholesterol and coronaries: from plaques to genes to statins. Cell 161, 161–172 (2015).Article

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