May 29, 2026
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Genetic PCSK9 inhibition via base editing appeared safe and demonstrated dose-dependent, durable reductions in PCSK9 and LDL cholesterol, researchers reported.At the highest dose, VERVE-102 (Verve Therapeutics) was associated with an up to 88% reduction in PCSK9 and a 62% reduction in LDL, and could represent a single-dose, lifelong therapeutic to prevent atherosclerotic CVD in people with
May 29, 2026
2 min read
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A single dose of Lilly's PCSK9 base editor, VERVE-102, reduced PCSK9 by up to 88% and LDL-C by up to 62%, with durable effects supporting its potential as a one-time treatment for hypercholesterolemia

So Far, So Good for PCSK9-Targeting Gene Therapy in Hypercholesterolemia

Gene-editing drugs are opening a new frontier in medicine

Bad cholesterol slashed 62% by single dose of gene-editing drug in small trial

One dose of gene-editing drug cut bad cholesterol 62% for months in small trial

Lilly reports new data on PCSK9 base editing gene therapy from Verve buyout

Eli Lilly says Verve’s gene editor lowers cholesterol levels in early study

Early data for heart drug affirm Lilly’s billion-dollar bet on Verve

Chamath Palihapitiya Said This To Eli Lilly's Gene Therapy That Slashes LDL Cholesterol Up To 62% - Eli L

Why researchers are excited about a one-time cholesterol therapy

A single dose of Lilly's PCSK9 base editor, VERVE-102, reduced PCSK9 by up to 88% and LDL-C by up to 62%, with durable effects…

Tweaked lipid nanoparticle delivery system showed early safety

Medicines that we take only a few times and which permanently alter the trajectory of our lives for the better, are on the way.

The interim Phase I trial data was only from 35 people, but results look good so far.

The interim Phase I trial data was only from 35 people, but results look good so far.

Eli Lilly said a base editing gene therapy from its purchase of Verve Therapeutics delivered additional positive results in a…