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Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover - Nature
Chronic dietary cholesterol activates Ral GTPases, which promote LDLR internalization and lysosomal degradation through RalBP1–REPS1 and CTSA, thereby reducing cholesterol clearance, whereas CTSA inhibition restores LDLR function and may offer a therapeutic strategy for cardiovascular disease.
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Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover - Nature
Chronic dietary cholesterol activates Ral GTPases, which promote LDLR internalization and lysosomal degradation through RalBP1–REPS1 and CTSA, thereby reducing cholesterol…
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How long-term dietary cholesterol can slow down its own clearance by liver cells
Chronic exposure to cholesterol can move the receptor protein LDLR into cells for degradation.