The Protein Production and Structure Core Facility (PTPSP) empowers structure-guided drug discovery with expert know-how, advanced instrumentation and access to X-ray synchrotron beamtime.The PTPSP team provided state‑of‑the‑art X-ray crystallography expertise to the laboratory of Prof. Christian Heinis, generating high-quality structural data that was essential for understanding the molecular basis of peptide binding to its target. The structure reveals key polar and hydrophobic interactions underlying the high-affinity binding of the peptide, and those findings were instrumental for subsequent structure-activity relationship studies. The work from Ji et al highlights the value of integrated screening, structural biology, and modeling expertise, and showcases the important contributions of PTPSP platform in advancing innovative drug discovery research.ReferencesGeneration of membrane-permeable cyclic peptides inhibiting protein–protein interaction. Xinjian Ji, Lluc Farrera-Soler, Jiajun Li, Gontran Sangouard, Nathan De Sadeleer, Alexander L. Nielsen, Ganesh K. Mothukuri, Anne Zarda, Edward J. Will, Florence Pojer, Kelvin Lau & Christian Heinis . Nature Chemical Biology (2026)