Do people with obesity need to take a GLP-1 for the rest of their life?

Obesity is a chronic disease. This statement is clearly at the heart of the answer to this question. When you look at the data in the STEP 1 trial extension, semaglutide (Wegovy, Novo Nordisk) works very well. But among patients who stopped it, two-thirds regained most of their weight within a year. Then, when you look at the STEP 4 trial, which randomly assigned participants receiving