Oral anticoagulant therapy lowered the risk of adverse clinical events compared with no anticoagulation in patients with atrial fibrillation at intermediate stroke risk, according to results from the SINGLE-AF trial presented in a Hot Line session at ESC Congress 2026 and published simultaneously in the New England Journal of Medicine.

MUNICH — In patients with atrial fibrillation and intermediate risk for stroke, direct oral anticoagulants were linked to reduced risk for death, stroke and major bleeding…

SINGLE-AF trial shows cardiovascular protection without unacceptable bleeding