SORLA Upregulation as a Possible Means to Treat Tauopathies

A number of neurodegenerative conditions, including Alzheimer's disease, are characterized by a pervasive chemical alteration of tau protein that causes tau to cease its normal function and aggregate into structures known as neurofibrillary tangles. This is harmful to neurons and their normal, necessary function. The feedback loop between maladaptive inflammation and tau aggregation drives the...

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