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Integrated Stress Response Inhibition Slows Aging in Flies
The integrated stress response in cells acts to reduce protein synthesis while enhancing maintenance activities. A number of…
Sirtuin 1 as an Exerkine
Despite the failure to produce any useful approach to therapy based on upregulation of sirtuin 1 expression, and an entirely…
Antibody NG101 Promotes Nerve Regrowth Following Injury
Nerves are made up of bundled axons, the long connections between neurons, and so regeneration following injury involves new…
Dietary Change Can Shift the Klemera-Doubal Method Aging Clock by a Few Years
The primarily alternative to epigenetic clocks and other omics clocks to assess biological age is the use of aging clocks…
The Aging Gut Microbiome Dysregulates the Immune System in Intestinal Tissue
With advancing age the composition of the gut microbiome changes in detrimental ways and the immune system becomes progressively…
A Microglia Centered View of Age-Related Macular Degeneration
Microglia are innate immune cells of the central nervous system, analogous to macrophages elsewhere in the body. Overly reactive…
Fight Aging! Newsletter, May 18th 2026
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the…
A View of the Changing Field of Research into Cellular Senescence in Aging
The accumulation of senescent cells with age is clearly an important aspect of degenerative aging. Senescent cells contribute to…
HuR Inhibition in Platelets Attenuates Degenerative Aging in Mice
Platelets play a vital role in blood clotting. A population of hematopoietic cells known as megakaryocytes spawn platelets by…
Lipopolysaccharide Exposure Before Injury Improves Regeneration in Aged Skin
Researchers here report an surprising, interesting, but not immediately useful discovery relating to the interaction of the…
Examining Forms of Social Organization and Species Longevity in Mammals
The work noted here might be taken as a companion piece to a recent paper on eusociality as a driver of the evolution of…
Disruption of the Integrator Responsible for RNA 3′ End Processing Slows Aging…
Researchers have established a number of interventions in short-lived species that extend life as a result of degrading the…
An Accumulative Vesicle Load Hypothesis of Neurodegenerative Disease
All cells release and take up extracellular vesicles. This includes the bacteria present in the body, both the beneficial…
Epidemiological Data Indicates Lifestyle to Outweigh Genetics in Late Life…
The study noted here is one of many to show that the effects of lifestyle choice and environmental exposure far outweigh the…
Why Do Eusocial Species Tend Towards Greater Longevity?
Long-lived naked mole-rats are eusocial: like ants and bees, they live in colonies led by a queen that is the only female that…