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An electron microscope breakthrough delivers sharper images of our body’s tiniest proteins
With its ability to determine 3D protein structures, cryo-EM revolutionized drug discovery. But it is limited to imaging the body’s largest proteins. UC Berkeley and Biohub physicists have now added powerful lasers to the electron microscope to produce much higher contrast — like phase contrast in optical microscopes— and potentially allow cryo-EM to resolve proteins one-quarter today’s limit. The “laser phase plate” offers a new window into the molecular machinery of the cell.
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news.berkeley.edu
A breakthrough in electron microscopy delivers sharper images of our body’s tiniest proteins - Berkeley News
UC Berkeley physicists have introduced phase contrast to the electron microscope, allowing scientists to see much smaller molecules and smaller structures inside cells.
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morningstar.com
Making the Invisible Visible: Microscope Breakthrough Will Open Unprecedented View into Our Cells
Making the Invisible Visible: Microscope Breakthrough Will Open Unprecedented View into Our Cells
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nature.com
An innovative technology boosts image quality for protein structures
After years of effort, two research teams have developed ‘laser phase plate’ systems that could help cryo-electron-microscopy users to generate high-quality structures for a broad…
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eurekalert.org
An electron microscope breakthrough delivers sharper images of our body’s tiniest proteins
With its ability to determine 3D protein structures, cryo-EM revolutionized drug discovery. But it is limited to imaging the body’s largest proteins. UC Berkeley and Biohub…