Russia launched a large-scale missile and drone attack on Kyiv overnight into Wednesday, killing at least five people and injuring 35 others, Ukrainian media said.

Residential buildings, a school and several warehouses were reportedly damaged in the strikes, signalling a definitive end to a temporary suspension of hostilities in Kyiv and Moscow during a weekend visit by US envoys.

Elsewhere in Ukraine, a Russian drone strike killed civilians at a checkpoint on the border with Moldova, the State Border Guard Service of Ukraine said on Wednesday.

"During the night, Russia attacked the Starokozache international road checkpoint on the border with Moldova with strike UAVs (unmanned aerial vehicles)," the service wrote in a post on Telegram.

The strike killed and wounded civilians who were near the checkpoint and caused fires, it said, without specifying the number of people hurt.