Anxiety and depression have been extensively studied in patients with inflammatory bowel disease (IBD), but research has rarely investigated the pre-diagnostic period.In a Swedish cohort study, the relative rate of any psychiatric disorder started to increase 2-3 years before IBD diagnosis, peaked soon after diagnosis, and rapidly decreased post diagnosis, but remained elevated at 10 years.This increased risk was mainly driven by major depressive disorders, anxiety disorders, and substance misuse.
Patients with inflammatory bowel disease (IBD) were at increased risk for several psychiatric disorders both before and after diagnosis, according to results from a Swedish cohort study.
The relative rate of any psychiatric disorder started to increase 2-3 years before IBD diagnosis (HR 1.15, 95% CI 1.09-1.21, at -2 years), and peaked immediately after IBD diagnosis (HR 1.50, 95% CI 1.41-1.59, at 0.5 year), reported Jiangwei Sun, PhD, of the Karolinska Institutet in Stockholm, and colleagues.
That risk rapidly decreased in the years after IBD diagnosis, but remained elevated even at 10 years (HR 1.19, 95% CI 1.13-1.24), they wrote in Clinical Gastroenterology and Hepatology.
The increased risk was mainly driven by major depressive disorders, anxiety disorders, and substance misuse, while no increase was observed for psychotic disorders, personality disorders, and attention deficit-hyperactivity disorder. IBD patients were more likely to have autism spectrum disorders shortly after diagnosis, and eating disorders 5 or more years onwards.
