One of the largest investigations yet into coffee and liver health has found that people who drink more coffee tend to have lower risks of cirrhosis, liver cancer, and death related to liver disease.

The Cedars-Sinai Health Sciences University study, published in Clinical Gastroenterology and Hepatology, also uncovered biological patterns that could help explain why coffee consumption has repeatedly been associated with healthier livers.

"Previous studies suggested that coffee might benefit the liver, but most were smaller or looked at only one piece of the puzzle," said hepatologist Hyunseok Kim, MD, MPH, PhD, assistant professor of Medicine at Cedars-Sinai and corresponding author of the study. "We followed hundreds of thousands of people for more than a decade and looked at their health outcomes along with liver MRI scans and blood protein analyses. Together, those findings help explain the biological mechanisms behind coffee's association with better liver health."

Study Followed Nearly 355,000 Adults

Researchers examined data from 354,957 UK Biobank participants who had no history of cirrhosis or liver cancer when the study began. Using linked medical records, the team tracked new cases of cirrhosis, liver cancer, and liver-related death over a median period of 13 years.