Data availabilityAll relevant data are included in the paper and/or its supplementary information files. Source Data are provided for all main figures (Figs. 1–5) and Extended Data figures (Extended Data Figs. 1, 2, 4 and 7–12), either as separate files or, where noted in the figure legends, as part of Supplementary Fig. 4. The raw data for the RNA-seq experiments in Fig. 1, Extended Data Fig. 5 and Supplementary Fig. 1 have been deposited to the National Center for Biotechnology Information (NCBI) with the BioProject accession number PRJNA1159167. This study also made use of the NCBI GenBank database (https://www.ncbi.nlm.nih.gov/genbank/) for bacterial genome retrieval and for the systematic identification of CRISIS systems, as detailed in the Methods. All strains and plasmids are available from the corresponding author upon request; requests will be answered within 2 weeks. Source data are provided with this paper.ReferencesHampton, H. G., Watson, B. N. J. & Fineran, P. C. The arms race between bacteria and their phage foes. Nature 577, 327–336 (2020).Article
PubMed
Google Scholar
Georjon, H. & Bernheim, A. The highly diverse antiphage defence systems of bacteria. Nat. Rev. Microbiol. 21, 686–700 (2023).Article






