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At least 16 people killed, dozens injured after a bus they were traveling in overturned in Eastern Cape province, South Africa. [File, Standard]

A passenger bus carrying 78 people overturned in southwest South Africa on Thursday, killing at least 16 people, including children, police and transport officials said.

South Africa has one of the continent's most developed road networks, but continues to struggle with a high rate of road deaths, largely blamed on speeding, reckless driving, unroadworthy vehicles and the failure to use seat belts.

The bus was travelling from the tourist city of Cape Town to Idutywa in Eastern Cape province when it crashed in the early hours, the Road Traffic Management Corporation (RTMC), a government road safety partnership, said.