October 23, 2025
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Sacituzumab govitecan significantly improved survival outcomes for previously untreated, PD-L1-negative metastatic triple-negative breast cancer compared with chemotherapy, according to results from a randomized phase 3 trial.Findings from ASCENT-03, presented at ESMO Congress and co-published in The New England Journal of Medicine, showed patients who received sacituzumab govitecan (Trodelvy,
October 23, 2025
4 min read
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CHICAGO — In this video, Megan Kruse, MD, breast medical oncologist at Cleveland Clinic, discusses primary results from ASCENT-04…

CHICAGO — In this video, Sara A. Hurvitz, MD, FACP, discusses the ASCENT-03 study, which showed treatment with sacituzumab…

CHICAGO — New findings from the randomized phase 3 ASCENT-04 trial reinforce prior research that first-line sacituzumab govitecan…

The FDA has approved sacituzumab govitecan-hziy as first-line therapy for adults with unresectable locally advanced or metastatic…

Sacituzumab govitecan approved alone or in combination for first-line treatment

ASCENT-04 analysis finds PFS2 advantage as an indicator of long-term clinical benefit