The mother of “Today” show host Savannah Guthrie is missing in Arizona, and law enforcement made concerning statements about her well-being.

“I hope we find her safe and sound, but we can’t ignore what’s in front of us,” Pima County Sheriff Chris Nanos said of Nancy Guthrie after authorities encountered aspects of “grave concern” in a search of her home near Tucson.

Nanos, citing her family, said Guthrie, 84, has “physical ailments” that limit her mobility but is cognitively sound.

She has been missing since Saturday and was last seen at her residence that night, according to a missing persons flyer.

Nanos said she may have been exposed to cold weather overnight while the department is also exploring possible foul play.