You might have seen this compound on the shelves of your local pharmacy.

Traditionally used in herbal medicine, berberine is now commonly stocked as a supplement at stores in the United States.

Interest in berberine supplements took off in 2023, with Google searches reaching an all time high in June of that year. Search berberine on TikTok and you'll find countless videos discussing the supplement’s weight loss potential – with some going as far as to brand it “nature’s Ozempic.”

Beyond weight loss, berberine also has a few other potential benefits to be aware of. Recent research has investigated berberine’s role in supporting heart health and lowering blood sugar levels, per Healthline.

How do berberine supplements hold up against prescription medication? Here’s what experts have to say.