Melatonin, a sleep hormone, shows potential for easing long-term muscle and joint discomfort. This hormone may dampen pain signals and reduce inflammation throughout the body. However, the pain relief achieved is modest and not significant for surgical recovery. Dosage and optimal usage duration for pain relief remain unclear from current studies. While generally safe, individuals with certain health conditions should consult a doctor before use.

The natural hormone melatonin plays a key role in lulling us to sleep and so is widely prescribed in synthetic form as a sleep aid.

Sleep and pain are closely linked (poor sleep can make pain feel worse, and pain can make sleep harder)