Researchers from Kansas City University School of Medicine have published a scoping review examining the role of astrocytes in chronic traumatic encephalopathy (CTE). Synthesizing evidence from 40 studies, the review suggests that astrocytic dysfunction, neuroinflammation, impaired waste clearance, and disrupted glutamate homeostasis may contribute significantly to disease development and progression. The findings support a shift from a neuron-centric view of CTE toward a broader neuroglial disease model.