A Mechanism to Explain the Age-Related Failure to Resolve Fibrosis in the Lung

Pulmonary fibrosis is an age-related condition. Good evidence connects it to the burden of senescent cells in the aging lung, but its causes are otherwise relatively poorly understood. Therapeutic options remain poor, and the prognosis for patients is quite ugly. Fibrosis is nanoscale scarring, an inappropriate buildup of excess extracellular matrix that is disruptive to...

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