From static labels to dynamic trajectories in steatotic liver disease

A new conceptual article published in eGastroenterology proposes that metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction and alcohol-associated liver disease (MetALD), and alcohol-associated liver disease (ALD) should be viewed as a dynamic continuum rather than fixed diagnostic entities. The authors highlight how fluctuations in alcohol intake and metabolic dysfunction drive transitions across disease categories over time. The work also emphasizes objective alcohol biomarkers, particularly phosphatidylethanol (PEth), as emerging tools for improving risk stratification and personalized management in steatotic liver disease.

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