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How long-term dietary cholesterol can slow down its own clearance by liver cells
Chronic exposure to cholesterol can move the receptor protein LDLR into cells for degradation.
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nature.com
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Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover - Nature
Chronic dietary cholesterol activates Ral GTPases, which promote LDLR internalization and lysosomal degradation through RalBP1–REPS1 and CTSA, thereby reducing cholesterol…
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How long-term dietary cholesterol can slow down its own clearance by liver cells
Chronic exposure to cholesterol can move the receptor protein LDLR into cells for degradation.