Cassidy's loss does not bode well for other incumbents, like Rep. Thomas Massie, who have earned themselves a challenge from Trump-backed candidates.

The president's revenge tour against GOP dissenters goes through Louisiana, where incumbent Sen. Bill Cassidy faces two MAGA rivals.

Trump endorsed U.S. Rep. Julia Letlow over Cassidy, in an unusual attempt to dislodge an incumbent senator. Cassidy voted to convict Trump in his second impeachment trial.

Rep. Thomas Massie is in the political fight of his life as the most outspoken congressional Republican against the president.

President Donald Trump criticized Rep. Thomas Massie as "worse" than Sen. Bill Cassidy after Cassidy's primary defeat, viewing them disloyal.