Following a splashy offseason filled with massive defensive upgrades, the Los Angeles Rams are one of the biggest preseason Super Bowl favorites in recent NFL history — only the dynastic New England Patriots and Kansas City Chiefs have had odds as short as the Rams do to open a season over the past decade.A trade for single-season sack king Myles Garrett coupled with the return of retired future Hall of Fame defensive tackle Aaron Donald gives the Rams perhaps the most menacing combination of pass rushers ever seen. When added to a contender nucleus that already features reigning MVP Matthew Stafford along with top targets Puka Nacua and Davante Adams, it’s easy to see why star-studded Los Angeles is grabbing preseason headlines.The revamped defense helped create significant separation between the Rams and every other NFL team on Super Bowl oddsboard. Can they live up to the hype and become the first preseason favorites to claim the Lombardi Trophy since the Chiefs in 2023?Super Bowl oddsRams in rare company as heavy favoritesAt +500 odds, Los Angeles is the clear favorite to win the Super Bowl entering the 2026 NFL season. The Buffalo Bills (+1000), Baltimore Ravens (+1000) and defending Super Bowl champion Seattle Seahawks (+1200) are the closest current contenders on BetMGM.The Rams created this much separation by overhauling a solid defense with four noteworthy starters during a monster offseason.By adding cornerbacks Trent McDuffie and Jaylen Watson, Los Angeles addressed playmaking concerns in the secondary. Trading for Garrett, the reigning Defensive Player of the Year, then vaulted the Rams from +800 to +600. Now after also adding Donald, they possess the largest preseason gap between the top two teams in Super Bowl odds since the 2017 New England Patriots (+275) opened that season as comfortable favorites over the Seattle Seahawks, Green Bay Packers and Oakland Raiders (all +800).