The Los Angeles Rams are loaded, Patrick Mahomes has a new knee, the Super Bowl champs are somehow underdogs and Buffalo Bills fans are once again convincing themselves this is the year!

It’s all happening in the NFL. Here are five things to know about Week 1 of the 2026 season.

The Los Angeles Rams enter the season as huge favorites to win the Super Bowl, which will be played in LA for the first time since… the Rams won the Super Bowl in 2022.

It’s been a blockbuster offseason for the Rams. They made a huge trade, sending three draft picks, including a first-rounder, to the Browns for superstar pass rusher Myles Garrett. They also made a big trade with the Chiefs, sending four draft picks, including a first-rounder, for star cornerback Trent McDuffie.

Those moves instantly made the Rams one of the scariest defenses in the league. And that was BEFORE arguably the best defensive player of all time decided to come out of retirement.