Glioblastoma is among the most lethal forms of cancer, and treatment options have changed relatively little because the tumors frequently withstand both radiation and chemotherapy. Researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute have now identified a protein called SET as a possible target that could make glioblastoma cells easier to kill with existing therapies.
Rather than replacing current treatments, the strategy is designed to help them work better. In preclinical experiments, suppressing SET prevented tumors from developing.
A Potential Weakness in Glioblastoma
Among the proteins examined, SET stood out because blocking it had such a strong effect on tumor formation. The researchers also found that interfering with related proteins increased the sensitivity of glioblastoma cells to radiation.
Together, the findings point to a biological pathway that may eventually be targeted with drugs to weaken the cancer's defenses.
