Police in New York shot and killed a 49-year-old woman after she allegedly stabbed two people in Times Square before refusing repeated orders to drop two knives, authorities said.

The incident occurred on Monday afternoon along Seventh Avenue near West 42nd Street, one of the busiest areas of Manhattan, with thousands of commuters, tourists and families in the area at the time.

According to New York Police Department Commissioner Jessica Tisch, officers confronted Pamela Cisneros after she allegedly attacked the two victims within about 20 seconds.

The first victim, a 32-year-old woman, was stabbed in the abdomen and later died in hospital. A 68-year-old man was also stabbed in the abdomen but remained in stable condition.

Tisch said officers spent about four minutes trying to get Cisneros to surrender her weapons before using force.