At least 22 people were killed and hundreds of others were went missing in Nepal Wednesday when an avalanche triggered massive flash floods.

Officials said 384 tourists, including 291 from countries such as India, the United States, the United Kingdom and Malaysia, were reported missing.

The Bhotekoshi River flooded around 9 a.m. local time Wednesday, destroying several villages, roads and hydropower projects, officials said.

"We have asked both India and China to help us with the rescue efforts," said Sasmit Pokharel, a spokesperson for the Nepali government.

Dozens of multistoried buildings, trucks, and vans were buried under vast quantities of mud in the district of Nuwakot, one of the worst-affected areas.