‘We were surprised’: Study reveals molecular basis for rheumatoid arthritis pathogenesis

A deep analysis of synovial tissue from patients with rheumatoid arthritis revealed fibrin-rich niches containing SPP1hi macrophages and remodeling fibroblasts, which may provide future therapeutic targets.In a study published in Science Translational Medicine, Ian Mantel, PhD, a postdoctoral fellow at Hospital for Special Surgery and Weill Cornell Medicine, and colleagues noted that the