Changes in gene activity may contribute to neck and back pain by damaging the discs that act as the spine's natural shock absorbers, according to new research.
A study using zebrafish found that altered gene activity can cause minerals to accumulate within the spine. This process resembles bone forming where it should not, eventually making spinal tissue unusually hard.
Researchers say the results reveal several biological processes that could become targets for future back pain treatments. The work also indicates that zebrafish may provide a useful model for testing potential therapies.
Why Spinal Discs Break Down
Most people experience back pain at some point. A major cause is the progressive deterioration of the discs that cushion the bones of the spine, a condition called intervertebral disc degeneration (IVDD).
