Data availabilityThe analysis results and bioinformatics data have been deposited into the Zenodo61 repository 19803100 (https://zenodo.org/records/19803100). scRNA-seq or single-nucleus RNA-seq datasets of astrocytes were obtained from the Gene Expression Omnibus with accession numbers GSE150858 (ref. 2), GSE130119 (ref. 8), GSE180759 (ref. 29) and the BioProject repository PRJNA544731 (ref. 30). All other data are available from the corresponding author on reasonable request. Correspondence and request for materials should be addressed to F.J.Q. Source data are provided with this paper.ReferencesLee, H. G., Lee, J. H., Flausino, L. E. & Quintana, F. J. Neuroinflammation: an astrocyte perspective. Sci. Transl. Med. 15, eadi7828 (2023).Article

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