Antipsychotics are mostly used off-label for young people, for conditions including autism spectrum disorder-related irritability, attention deficit-hyperactivity disorder, anxiety, and sleep disturbances.Initiation of antipsychotic medications was linked to an increase in the prevalence of pharmacologically treated type 2 diabetes in youths in a Dutch cohort study.Recurrent users had greater and increasingly higher risks of pharmacologically treated type 2 diabetes, but this observed increased risk persisted even among those who used antipsychotics only in the first year they were dispensed.
Initiation of antipsychotic medications, even for short durations, was linked to an increase in the prevalence of pharmacologically treated type 2 diabetes in youths, according to a Dutch cohort study.
Among nearly 90,000 youths taking antipsychotic medications, the annual risk difference increased from 2.47 per 10,000 users in the initiation year to 9.02 per 10,000 users by year 5, reported Ravish Nilish Gangapersad, MSc, of Erasmus University Medical Center in Rotterdam, the Netherlands, and co-authors.
The corresponding change in relative risk was 0.89 (95% CI 0.39-1.39) in year 0, rising to 1.84 (95% CI 1.13-2.55) in year 1, and to 3.25 (95% CI 2.15-4.34) in year 5, they wrote in JAMA Network Open.
