ViiV Healthcare’s 2-drug regimen Dovato is as effective as 3-drug regimen Biktarvy in first-of-its-kind head-to-head study in treatment-naïve adults living with HIV

ViiV Healthcare’s 2-drug regimen Dovato is as effective as 3-drug regimen Biktarvy in first-of-its-kind head-to-head study in treatment-naïve adults living with HIV

Positive Week 48 data from the phase IIIb VOGUE study reinforce Dovato as an effective treatment option with fewer medicines than Biktarvy, across diverse populations

Findings build on 10 years of evidence supporting DTG/3TC as the first and only oral 2-drug regimen for treatment-naïve people living with HIV

ViiV Healthcare, the global specialist HIV company majority owned by GSK, with Shionogi as a shareholder, today announced data to be presented this week at the 26th International AIDS Conference (AIDS 2026) in Rio de Janeiro, Brazil, from the phase IIIb VOGUE study. Data show that Dovato (dolutegravir/lamivudine (DTG/3TC)) demonstrated non-inferior efficacy to Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF)) in treatment-naïve adults living with HIV, including people with high viral loads or a low CD4+ cell count.1 The findings also reinforced DTG/3TC’s high barrier to resistance, with zero cases of treatment-emergent resistance identified across treatment arms.

Jean van Wyk, MBChB, MFPM, Chief Medical Officer at ViiV Healthcare, said: "HIV treatment is lifelong, so the number of medicines people take over decades of care can matter. As the first randomised, head-to-head study comparing DTG/3TC with BIC/FTC/TAF in treatment-naïve adults living with HIV, VOGUE adds to 10 years of real-world evidence showing that people starting treatment can successfully manage their HIV with fewer daily drugs. The data demonstrate that from day one, we can potentially reduce the number of antiretroviral drugs a person receives with DTG/3TC, without compromising on efficacy or the barrier to resistance.”