TL;DRFederal agencies pledged over $5 billion to the Genesis Mission, funding 278 AI-for-science projects selected from more than 5,000 applications

Federal agencies have committed more than $5 billion to the Genesis Mission, an Energy Department-led effort to use artificial intelligence to accelerate scientific research, White House science adviser Michael Kratsios announced on Wednesday. The initiative selected 278 projects from more than 5,000 applications, Energy Secretary Chris Wright said at a summit in Washington. More than 15 federal agencies are contributing research awards, funding, datasets, and facilities to the programme.

The Genesis Mission was established by a November 2025 executive order and is part of what the administration describes as the largest marshalling of federal scientific resources since the Apollo programme. Under Secretary for Science Dario Gil, who is directing the effort for the Energy Department, said the mission brings together leading researchers, institutions, and technology partners to build what he called the next generation of scientific capability. The DOE received the largest response rate for any programme in the department’s history, according to Gil.