July 22, 2026
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In this Healio video exclusive, Leonard H. Calabrese, DO, chief medical editor of Healio Rheumatology, highlights recent coverage regarding the FDA’s effort to revoke its approval of avacopan for ANCA-associated vasculitis.The FDA has alleged that employees of the drug’s original manufacturer, ChemoCentryx, manipulated data in the ADVOCATE trial, which was the sole study the FDA
July 22, 2026
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The FDA has proposed to withdraw its approval of avacopan for ANCA-associated vasculitis, alleging that employees of the original…

The New England Journal of Medicine has retracted its publication of the sole trial of avacopan used by the FDA to assess the…

Agency has been calling for the vasculitis drug to be pulled from the market since January

Move follows actions 'inconsistent with proper research conduct,' journal says

Trial data 'can no longer be relied upon' to demonstrate drug's efficacy, EMA committee says

With all eyes on Tavneos’ seemingly precarious approval status in the U.S., Amgen is advancing plans to defend the…