Sirolimus gel improves appearance of acanthosis nigricans, hallmark of insulin resistance

Twice daily sirolimus gel 0.2% was effective and safe for the treatment of acanthosis nigricans, a common dermatologic condition that predominantly affects people with skin of color, according to a study. Participants saw a significant reduction in the pigmentation of the plaques within 12 weeks, with the earliest signs of improvements appearing at week 4, according to findings published in the