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A recent study investigated the association between the use of hydroxychloroquine (HCQ) in pregnant women with systemic lupus erythematosus (SLE) and the risks of preeclampsia/eclampsia and preterm delivery. The main objective was to determine whether HCQ has a protective effect against preeclampsia.

The report, which appears in Arthritis Care & Research, studied 847 pregnancies among 597 publicly insured women with SLE in a Canadian data registry.

Co-author, Julia Simard, ScD, is an associate professor with the department of epidemiology and population health with Stanford University School of Medicine in California. Simard recently discussed the paper and its findings with the Reading Room. The exchange has been edited for length and clarity.

What was the context that motivated this report, and what was the key question it was designed to answer?