June 25, 2026
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The FDA has approved olezarsen as the first and only therapy, alongside diet, to lower triglycerides and acute pancreatitis risk in patients with severe hypertriglyceridemia, according to a manufacturer press release.Olezarsen (Tryngolza, Ionis Pharmaceuticals), an apolipoprotein C-III inhibitor, is administered once monthly by autoinjector and is available in 50 mg and 80 mg doses. As Healio
June 25, 2026
2 min read
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Severe Hypertriglyceridemia Drug Approved to Reduce Triglycerides, Pancreatitis Risk

TRYNGOLZA® (olezarsen) approved by the FDA as the first and only treatment to reduce triglycerides and the risk of acute pancreatitis in patients with severe hypertriglyceridemia (sHTG)

Ionis Climbs As FDA Clears New Therapy To Lower Triglycerides, Pancreatitis Risk - Ionis Pharmaceuticals

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Olezarsen indicated as an adjunct to diet

TRYNGOLZA® (olezarsen) approved by the FDA as the first and only treatment to reduce triglycerides and the risk of acute…

In patients with severe hypertriglyceridemia, olezarsen lowered triglycerides and reduced acute pancreatitis events compared with…

Ionis wins FDA approval for Tryngolza in severe hypertriglyceridemia and signs a Recordati licensing deal for zilganersen

Ionis wins FDA approval to expand Tryngolza into severe hypertriglyceridemia, a far larger market than its rare FCS launch, with…

After 35 years engaged in the research and development of pharmaceutical products, Ionis began marketing its drugs for the first…