TRYNGOLZA® (olezarsen) approved by the FDA as the first and only treatment to reduce triglycerides and the risk of acute pancreatitis in patients with severe hypertriglyceridemia (sHTG)

– Proven to deliver significant and robust triglyceride reductions –

– Only treatment for sHTG indicated to reduce the risk of acute pancreatitis –

– Ionis’ first independent commercial launch in a prevalent condition –

– Ionis to host webcast today at 3:30 p.m. ET –